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Pompe disease symptoms | Pompe Disease News | illustration of doctor talking to patient

Symptoms of Pompe Disease

Last updated Aug. 4, 2022, by Marisa Wexler, MS

✅ Fact-checked by Patrícia Silva, PhD

Pompe disease can cause a range of symptoms, based on age of onset, rate of progression, and disease type

FAQs about Pompe disease symptoms

Across all types of Pompe disease, nearly all patients experience muscle weakness. Breathing problems and difficulty eating also are common in people with Pompe. Almost all babies with the classic infantile-onset form of the disease develop an enlarged heart and heart disease

Pompe disease is caused by a genetic mutation that renders the body unable to break down glycogen, a complex sugar molecule used by some cells as a form of short-term energy storage. Muscle cells, which require a lot of energy to power movements, normally store significant amounts of glycogen, thus muscles are primarily affected in Pompe. Cells of the heart and skeletal muscles (muscles responsible for the movements of body parts) are the most affected.

When a person breathes, muscles in the diaphragm work to push air in and out of the lungs. Pompe disease can cause weakness in these muscles — and likely also in other accessory respiratory muscles — which can ultimately lead to impaired breathing.

The speed of Pompe progression varies widely from person to person, depending on the type of disease as well as treatments and other factors. In general, an earlier onset of symptoms is associated with a faster disease progression.

Every person inherits two copies of the GAA gene, one from each biological parent. Pompe will only develop if both copies of this gene contain a disease-causing mutation. Carriers, who have only one mutated copy (and one healthy copy), will not develop Pompe symptoms, but they may pass the disease-causing mutation to their biological children.

Pompe Disease News is strictly a news and information website about the disease. It does not provide medical advice, diagnosis, or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.


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