Author Archives: Stacy Grieve, PhD

Methotrexate Seen to Counter Immune Reaction to Enzyme Replacement Therapy in Small Study

Low-dose treatment with methotrexate can reduce the immune reaction that often accompanies enzyme replacement therapies in infants with Pompe disease, researchers report. Their study, “An immune tolerance approach using transient low-dose methotrexate in the ERT-naïve setting of patients treated with a therapeutic protein: experience in infantile-onset Pompe…