Infusion-associated reactions to ERT mostly mild, nonallergic in Pompe

Hypersensitive reactions to infusions of enzyme replacement therapies (ERT) to treat late-onset Pompe disease (LOPD) were primarily mild and nonallergic, a small study reported. Many reactions were reported after a year of well tolerated ERT and most of them occurred in women, data showed. After the reactions, the ERT…

Allergic Reactions to ERT Can Be Managed for Continued Treatment, Study Indicates

Children receiving enzyme replacement therapy (ERT) for Pompe disease often experience immune reactions to treatment, presenting as rashes or severe allergy, sometimes after several successful infusions, a case series shows. While these hypersensitivity reactions can be avoided successfully with anti-allergy medications and longer infusion times in some patients, others…